PamGene


PamStation®12	PamChip®4

Immunkemi F&D lanserar PamGene’s mikroarray-teknologi för multiplex-analyser av proteinkinas-aktivitet. Analysen som bygger på fluorescensmätning av 144 unika peptidsekvenser sker i realtid och analyserar ett brett spektrum av kinas-aktiviteter i provet. Tekniken är flexibel då såväl celler som vävnader kan analyseras och proteinmängden som krävs i ett prov är 0,5 µg.

Användningsområdet innefattar identifiering av cellsignaleringsvägar och av diagnostiska/prognostiskska bio-markörer, toxikologi- och drugdiscovery studier.

Den användarvänliga analystekniken innefattar det CE-märkta instrumentet PamStation®12 , PamChip®4 arrayer samt BioNavigator, en mjukvara som presenterar data så att forskaren enkelt och intuitivt kan se skillnader mellan olika prover. Teknologin som är utvecklad av PamGene International B.V. är ett stort steg framåt för cellmekanistiska studier.

Vänligen kontakta Damir Zadravec, 086231426, Damir@immunkemi.se, för ytterligare information om PamGene.

Klicka på följande länkar för applikationsbroschyrer

Teknologin

PamChip® microarrays and PamStation® instruments; A novel platform to support kinase and kinase inhibitor research

Functional testing of PamStation®12 microarray instrument performance

BioNavigatoR, software to interpret PamChip® measurements

Protein tyrosine kinase assay robustness on PamChip® microarrays and PamStation®12

Applikationer

Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling

PamChip® arrays to support mechanistic studies to understand why PTEN inactivation leads to resistance to EGFR kinase inhibitors.

Development of Selective Bisubstrate-Based Inhibitors against Protein Kinase C (PKC) Isozymes

Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A

Kinome Profiling in Pediatric Brain Tumors; a New Approach for Target Discovery

Episodic Src activation in uveal melanoma revealed by kinase activity profiling

Prediction of survival in early stage non-small cell lung cancer (NSCLC) by kinase activity profiles

Application of kinase activity profiles to predict response to erlotinib in a neoadjuvant setting in early stage non-small cell lung cancer (NSCLC).

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases

Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos

Kinase activity as a sensor for efficacy of doxorubicin and/or bevacuzimab treatment of breast cancer

Endogenous Phosphotyrosine Signaling in Zebrafish Embryos

Application of kinase activity profiles to predict upcoming TKI resistance in CML-patients

Understanding downstream signaling of the kinase RET WT and mutant.

Kinase activity profiling can visualize differential modulation of kinaseactivity by therapeutic Ab’s against the same growth factor receptor.

Using pathway analysis with PamChip® measurements to discover potential on/off target effects of a compound

Substrate identification and kinetic characterisation of JAK family kinases by multiplex kinase activity profiling

Substrate profiling of protein tyrosine kinases by multiplex kinase activity profiling

Immunkemi F&D AB | Tingsvägen 19 | 191 61 Sollentuna | Tel: 08-583 615 00 Fax: 08-583 615 01 | sales@immunkemi.se

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